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1

Identifying stereoisomers of the asymmetric hydrogenation catalyst [Me-BPE-Rh(COD)]+BF

Martin E. Fox, Raymond McCague

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 281 KB

english, 2005

2

Derivatives of tamoxifen. Dependence of antiestrogenicity on the 4-substituent

McCague, Raymond, Leclercq, Guy, Legros, Nicole, Goodman, Joyce, Blackburn, G. Michael, Jarman, Michael, Foster, Allan B.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 1.02 MB

english, 1989

3

An Enantioconvergent Synthesis of (R)-4-Aryloxy-1-butyne-3-ols for Prostanoid Side Chains

Martin E. Fox, Mark Jackson, Ian C. Lennon, Raymond McCague, Julian S. Parratt

Journal:

Advanced Synthesis & Catalysis

Année:

2002

Langue:

english

Fichier:

PDF, 133 KB

english, 2002

4

Oszillierende Kristallisation der (+)- und (−)-Enantiomere von 2-Azabicyclo[2.2.1]hept-5-en-3-on während der Trennung durch selektive Kristallisation

Gerard A. Potter, Chantal Garcia, Raymond McCague, Brian Adger, André Collet

Journal:

Angewandte Chemie

Année:

1996

Langue:

german

Fichier:

PDF, 419 KB

german, 1996

5

Oscillating Crystallization of (+) and (–) Enantiomers during Resolution by Entrainment of 2-Azabicyclo[2.2.1]hept-5-en-3-one

Dr. Gerard A. Potter, Dr. Chantal Garcia, Dr. Raymond McCague, Dr. Brian Adger, Prof. André Collet

Journal:

Angewandte Chemie International Edition

Année:

1996

Langue:

english

Fichier:

PDF, 598 KB

english, 1996

6

Octafluorotoluene as a derivatizing agent for steroids in human plasma

Michael H. Baker, Ian Howe, Michael Jarman, Raymond McCague

Journal:

Biological Mass Spectrometry = Journal of Mass Spectrometry (Wiley)

Année:

1988

Langue:

english

Fichier:

PDF, 259 KB

english, 1988

7

ChemInform Abstract: Practical Radical Cyclizations Leading to the Construction of Near-Stereopure Quaternary Carbon Stereogenic Centres.

Raymond McCague, Robin G. Pritchard, Richard J. Stoodley, Douglas S. Williamson

Journal:

Année:

1999

Fichier:

PDF, 30 KB

1999

8

ChemInform Abstract: An Enantioconvergent Synthesis of (R)-4-Aryloxy-1-butyne-3-ols for Prostanoid Side Chains.

Martin E. Fox, Mark Jackson, Ian C. Lennon, Raymond McCague, Julian S. Parratt

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 38 KB

english, 2002

9

A Convergent Synthesis of the 11-Oxa Prostaglandin Analogue AL-12182(I).

Martin E. Fox, Mark Jackson, Ian C. Lennon, Raymond McCague

Journal:

Année:

2005

Fichier:

PDF, 9 KB

2005

10

Synthesis of 4-stannylated tamoxifen analogues; useful precursors to radiolabelled idoxifene and aziridinyl 4-iodotamoxifen

Raymond McCague, Gerard A. Potter

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

1994

Langue:

english

Fichier:

PDF, 321 KB

english, 1994

11

Synthesis of homochiral l-(S)-tert-leucine via a lipase catalysed dynamic resolution process

Nicholas J. Turner, James R. Winterman, Raymond McCague, Julian S. Parratt, Stephen J.C. Taylor

Journal:

Tetrahedron Letters

Année:

1995

Langue:

english

Fichier:

PDF, 230 KB

english, 1995

12

Unexpected stereoselectivity in the cis dihydroxylation of some 2-cyclopentene-1-carboxamides

Christopher F Palmer, Raymond McCague, Graham Ruecroft, Sean Savage, Stephen J.C Taylor, Christel Ries

Journal:

Tetrahedron Letters

Année:

1996

Langue:

english

Fichier:

PDF, 195 KB

english, 1996

13

Rhodium catalysed asymmetric hydrosilylation of ketones using phosphorus-containing oxazoline ligands

Louise M Newman, Jonathan MJ Williams, Raymond McCague, Gerard A Potter

Journal:

Tetrahedron: Asymmetry

Année:

1996

Langue:

english

Fichier:

PDF, 110 KB

english, 1996

14

A measure of the solid-solution extent useful for crystallisation resolution studies

Raymond McCague

Journal:

Tetrahedron Letters

Année:

2007

Langue:

english

Fichier:

PDF, 358 KB

english, 2007

15

Highly selective directed hydrogenation of enantiopure 4-(tert-butoxycarbonylamino)cyclopent-1-enecarboxylic acid methyl esters

Mark E.B Smith, Nadine Derrien, Michael C Lloyd, Stephen J.C Taylor, David A Chaplin, Raymond McCague

Journal:

Tetrahedron Letters

Année:

2001

Langue:

english

Fichier:

PDF, 84 KB

english, 2001

16

A route to conformationally restricted antioestrogens by coupling of a vinyl triflate with an aryl zinc chloride

Raymond McCague

Journal:

Tetrahedron Letters

Année:

1987

Langue:

english

Fichier:

PDF, 117 KB

english, 1987

17

On the economic application of DuPHOS rhodium(I) catalysts: a comparison of COD versus NBD precatalysts

Christopher J Cobley, Ian C Lennon, Raymond McCague, James A Ramsden, Antonio Zanotti-Gerosa

Journal:

Tetrahedron Letters

Année:

2001

Langue:

english

Fichier:

PDF, 122 KB

english, 2001

18

An efficient stereoselective synthesis of Z-(2S)- and Z-(2R)-2-tert-butoxycarbonylamino-6-hydroxyhex-4-enoic acid, key intermediates in the synthesis of (2S,4S,5R)-(−)- and (2R,4R,5S)-(+)-bulgecinine

Karen E. Holt, Jonathan P. Swift, Mark E.B. Smith, Stephen J.C. Taylor, Raymond McCague

Journal:

Tetrahedron Letters

Année:

2002

Langue:

english

Fichier:

PDF, 71 KB

english, 2002

19

Development of the biocatalytic resolution of 2-azabicyclo[2.2.1]hept-5-en-3-one as an entry to single-enantiomer carbocyclic nucleosides

Stephen JC Taylor, Raymond McCague, Richard Wisdom, Carol Lee, Karen Dickson, Graham Ruecroft, Fergal O'Brien, Jennifer Littlechild, Jennifer Bevan, Stanley M Roberts, Christopher T Evans

Journal:

Tetrahedron: Asymmetry

Année:

1993

Langue:

english

Fichier:

PDF, 709 KB

english, 1993

20

An analogue of the antioestrogen tamoxifen of sufficient rigidity to exist as distinct enantiomers: synthesis and conformational dynamics studies

Raymond McCague

Journal:

Tetrahedron: Asymmetry

Année:

1990

Langue:

english

Fichier:

PDF, 809 KB

english, 1990

21

An efficient route to all eight stereoisomers of a tri-functionalised cyclopentane scaffold for drug discovery

Mark E.B. Smith, Michael C. Lloyd, Nadine Derrien, Richard C. Lloyd, Stephen J.C. Taylor, David A. Chaplin, Guy Casy, Raymond McCague

Journal:

Tetrahedron: Asymmetry

Année:

2001

Langue:

english

Fichier:

PDF, 56 KB

english, 2001

22

Synthesis Of Monohydroxylated 2-Azabicyclo[2.2.1]heptan-3-ones.

Christopher F Palmer, Ben Webb, Susan Broad, Sharon Casson, Raymond McCague, Andrew J Willetts, Stanley M Roberts

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1997

Langue:

english

Fichier:

PDF, 473 KB

english, 1997

23

Use of hydrolases for the synthesis of cyclic amino acids

Richard C Lloyd, Michael C Lloyd, Mark E.B Smith, Karen E Holt, Jonathan P Swift, Philip A Keene, Stephen J.C Taylor, Raymond McCague

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 540 KB

english, 2004

24

The synthesis of (R)-(+)-lipoic acid using a monooxygenase-catalysed biotransformation as the key step

Brian Adger, M.Teresa Bes, Gideon Grogan, Raymond McCague, Sandrine Pedragosa-Moreau, Stanley M. Roberts, Raffaella Villa, Peter W.H. Wan, Andrew J. Willets

Journal:

Bioorganic & Medicinal Chemistry

Année:

1997

Langue:

english

Fichier:

PDF, 986 KB

english, 1997

25

Synthesis, conformational considerations, and estrogen receptor binding of diastereoisomers and enantiomers of 1-[4-[2-(dimethylamino)ethoxy]phenyl]-1,2-diphenylbutane (dihydrotamoxifen)

McCague, Raymond, Leclercq, Guy

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 1011 KB

english, 1987

26

Inhibition of enzymes of estrogen and androgen biosynthesis by esters of 4-pyridylacetic acid

McCague, Raymond, Rowlands, Martin G., Barrie, S. Elaine, Houghton, John

Journal:

Journal of Medicinal Chemistry

Année:

1990

Langue:

english

Fichier:

PDF, 877 KB

english, 1990

27

Esters of 3-Pyridylacetic Acid That Combine Potent Inhibition of 17.alpha.-Hydroxylase/C17,20-Lyase (Cytochrome P45017.alpha.) with Resistance to Esterase Hydrolysis

Barrie, S. Elaine, Chan, Ferdinand, Houghton, John, Jarman, Michael, McCague, Raymond, Rowlands, Martin G., Potter, Gerard A.

Journal:

Journal of Medicinal Chemistry

Année:

1995

Langue:

english

Fichier:

PDF, 928 KB

english, 1995

28

Heptafluoro-p-tolyl and tetrafluoro-4-pyridyl as novel and selective protecting groups for phenolic and alcoholic functions: synthesis and cleavage of perfluoroaryl ethers of steroids

Jarman, Michael, McCague, Raymond

Journal:

Journal of the Chemical Society Chemical Communications

Année:

1984

Langue:

english

Fichier:

PDF, 210 KB

english, 1984

29

Aspects of metabolism of tamoxifen by rat liver microsomes: Identification of a new metabolite: E-1-[4-(2-dimethylaminoethoxy)-phenyl]-1, 2-diphenyl-1-buten-3-ol N-oxide

Raymond McCague, Alison Seago

Journal:

Biochemical Pharmacology

Année:

1986

Langue:

english

Fichier:

PDF, 731 KB

english, 1986

30

Metabolism of tamoxifen by isolated rat hepatocytes: Identification of l-[4-(2-hydroxyethoxy)phenyl]-1-(4-hydroxyphenyl)-2 -phenyl-1-butene and the dependence of N-oxidation on oxygen availability

Iris B. Parr, Raymond McCague, Guy Leclercq, Susanna Stoessel

Journal:

Biochemical Pharmacology

Année:

1987

Langue:

english

Fichier:

PDF, 739 KB

english, 1987

31

The inhibitory effect of p-trifluoromethyl substitution on the hepatic microsomal metabolism of benzyl phenyl sulphide

Alison Seago, John Houghton, Raymond Mccague, Allan B. Foster, Paul L. Coe, Andrew Falshaw

Journal:

Biochemical Pharmacology

Année:

1987

Langue:

english

Fichier:

PDF, 456 KB

english, 1987

32

Metabolism of tamoxifen by isolated rat hepatocytes: Identification of the glucuronide of 4-hydroxytamoxifen

Raymond McCague, Iris B. Parr, Guy Leclercq, On-Tai Leung, Michael Jarman

Journal:

Biochemical Pharmacology

Année:

1990

Langue:

english

Fichier:

PDF, 752 KB

english, 1990

33

Variation of the inhibition of calmodulin dependent cyclic AMP phosphodiesterase amongst analogues of tamoxifen; Correlations with cytotoxicity

Martin G. Rowlands, Iris B. Parr, Raymond McCague, Michael Jarman, Phyllis M. Goddard

Journal:

Biochemical Pharmacology

Année:

1990

Langue:

english

Fichier:

PDF, 608 KB

english, 1990

34

Metabolism of the 4-iodo derivative of tamoxifen by isolated rat hepatocytes: Demonstration that the iodine atom reduces metabolic conversion and identification of four metabolites

Raymond McCague, Iris B. Parr, Benjamin P. Haynes

Journal:

Biochemical Pharmacology

Année:

1990

Langue:

english

Fichier:

PDF, 604 KB

english, 1990

35

Effect of estrogenic and antiestrogenic triphenylethylene derivatives on progesterone and estrogen receptors levels of MCF-7 cells

Nicole Legros, Guy Leclercq, Raymond McCague

Journal:

Biochemical Pharmacology

Année:

1991

Langue:

english

Fichier:

PDF, 526 KB

english, 1991

36

Evidence that tamoxifen binds to calmodulin in a conformation different to that when binding to estrogen receptors, through structure-activity study on ring-fused analogues

Raymond McCague, Martin G. Rowlands, Rachel Grimshaw, Michael Jarman

Journal:

Biochemical Pharmacology

Année:

1994

Langue:

english

Fichier:

PDF, 541 KB

english, 1994

37

Comparison between inhibition of protein kinase C and antagonism of calmodulin by tamoxifen analogues

Martin G. Rowlands, Joanna Budworth, Michael Jarman, Ian R. Hardcastle, Raymond McCague, Andreas Gescher

Journal:

Biochemical Pharmacology

Année:

1995

Langue:

english

Fichier:

PDF, 423 KB

english, 1995

38

Non-isomerisable antiestrogens related to tamoxifen

Raymond McCague, Michael Jarman, On-Tai Leung, Allan B. Foster, Guy Leclercq, Susanna Stoessel

Journal:

Journal of Steroid Biochemistry

Année:

1988

Langue:

english

Fichier:

PDF, 307 KB

english, 1988

39

Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis

Jarman, Michael, Barrie, S. Elaine, Deadman, John J., Houghton, John, McCague, Raymond, Rowlands, Martin G.

Journal:

Journal of Medicinal Chemistry

Année:

1990

Langue:

english

Fichier:

PDF, 622 KB

english, 1990

40

Synthesis of the Potent Antiglaucoma Agent, Travoprost

Boulton, Lee T., Brick, Dean, Fox, Martin E., Jackson, Mark, Lennon, Ian C., McCague, Raymond, Parkin, Nicholas, Rhodes, Darren, Ruecroft, Graham

Journal:

Organic Process Research & Development

Année:

2002

Langue:

english

Fichier:

PDF, 107 KB

english, 2002

41

Tricyclic [10]annulenes. Part 2. Synthesis of 7b-methyl-7bH-cyclopent[cd]indene

McCague, Raymond, Moody, Christopher J., Rees, Charles W.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Année:

1984

Langue:

english

Fichier:

PDF, 1.26 MB

english, 1984

42

AN EFFICIENT, LARGE-SCALE SYNTHESIS OF IDOXIFENE {(E)-1-[4-[2-( N -PYRROLIDINO)ETHOXY]PHENYL]-1-(4-IODOPHENYL)-2-PHENYL-1-BUTENE}

McCague, Raymond, Potter, Gerard A., Jarman, Michael

Journal:

Organic Preparations and Procedures International

Année:

1994

Langue:

english

Fichier:

PDF, 265 KB

english, 1994

43

Asymmetric hydrogenation of a 4,4-diaryl-3-butenoate; a novel approach to sertraline

T. Boulton, Lee, C. Lennon, Ian, McCague, Raymond

Journal:

Organic & Biomolecular Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 135 KB

english, 2003

44

Synthesis of enantiomerically pure ?-hydroxyaldehydes from the corresponding ?-hydroxycarboxylic acids: novel substrates for Escherichia coli transketolase

Humphrey, Andrew J., Turner, Nicholas J., McCague, Raymond, Taylor, Stephen J. C.

Journal:

Journal of the Chemical Society Chemical Communications

Année:

1995

Langue:

english

Fichier:

PDF, 292 KB

english, 1995

45

Highly stereoselective access to an (E)-vinyl bromide from an aryl ketone leads to short syntheses of (Z)-tamoxifen and important substituted derivatives

Potter, Gerard A., McCague, Raymond

Journal:

Journal of Organic Chemistry

Année:

1990

Langue:

english

Fichier:

PDF, 567 KB

english, 1990

46

Iodotamoxifen derivatives and use for estrogen receptor-positive breast cancer detection and therapy

McCague, Raymond

Journal:

International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology

Année:

1989

Langue:

english

Fichier:

PDF, 106 KB

english, 1989

47

A Convergent Synthesis of the 11-Oxa Prostaglandin Analogue AL-12182

Fox, Martin E., Jackson, Mark, Lennon, Ian C., McCague, Raymond

Journal:

Journal of Organic Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 191 KB

english, 2005

48

Conformational analysis of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione (rogletimide) and discovery of potent 5-alkyl derivatives

McCague, Raymond, Rowlands, Martin G.

Journal:

Journal of Medicinal Chemistry

Année:

1992

Langue:

english

Fichier:

PDF, 705 KB

english, 1992

49

Nonisomerizable analogs of (Z)- and (E)-4-hydroxytamoxifen. Synthesis and endocrinological properties of substituted diphenylbenzocycloheptenes

McCague, Raymond, Leclercq, Guy, Jordan, V. Craig

Journal:

Journal of Medicinal Chemistry

Année:

1988

Langue:

english

Fichier:

PDF, 869 KB

english, 1988

50

Hydroxy derivatives of tamoxifen

Foster, Allan B., Jarman, Michael, Leung, On Tai, McCague, Raymond, Leclercq, Guy, Devleeschouwer, N.

Journal:

Journal of Medicinal Chemistry

Année:

1985

Langue:

english

Fichier:

PDF, 1.03 MB

english, 1985